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( Epub 2019 Jun 30

doi: 10.1371/journal.pone.0216825 119 NehamaDDi IanniNMusioSDuHPataneMPolloBet al

Rapisarda, A

It acts as a physiological ligand for Fe 2 + , promoting assembly of iron-sulfur (Fe-S) clusters and biosynthesis of Fe-S proteins, which participate in essential biological functions including electron transfer, the Krebs cycle, maintenance of genome integrity, enzymatic catalysis, and iron homeostasis 15

These characteristics are a prerequisite for many applications from cellular therapy, tissue engineering, drug toxicity assessment, and disease modeling to basic developmental biology